The overarching goal of our research is to investigate the role of nutrition and microbiota on human health and disease we are particularly interested in exploring the potential implications of nutrition and microbiota on fertility, development and regeneration of tissues/organs.

From a preventative and/or regenerative medicine perspective, our goal is to develop nutritional interventions that mimic the metabolic effects of diets which augment the healthy gut microbiota, immune function, fertility, normal development, tissue healing and regeneration without leading to any abnormalities.

As well, our team is working on the development of cell & cell-based products and assays to improve individualised healthcare of local population. We have active projects investigating the role of human microbiota in fertility/subfertility and establishment of in-house procedures to replace the xenogeneic source of growth supplements to isolate and culture of human tissue derived cells in vitro for clinical applications.

We utilize state-of-the-art technical modalities including in vitro and in vivo models, and cell/tissue culture systems to address research enquiries.

1. Miyata S, Saku N, Akiyama S, Javaregowda PK, Ite K, Takashima N, Toyoda M, Yura K, Kimura T, Nishina H, Nakazawa A. Puromycin-based purification of cells with high expression of the cytochrome P450 CYP3A4 gene from a patient with drug-induced liver injury (DILI). Stem Cell Research & Therapy. 2022 Dec;13:1-2.
2. Tsuneishi R, Saku N, Miyata S, Akiyama S, Javaregowda PK, Ite K, Takashima N, Toyoda M, Kimura T, Kuroda M, Nakazawa A. Ammonia-based enrichment and long-term propagation of zone I hepatocyte-like cells. Scientific Reports. 2021 May 31;11(1):11381.
3. Huh SW, Shetty AA, Kim JM, Cho ML, Kim SA, Yang S, Kim YJ, Javaregowda PK, Choi NY, Kang J, Kim SJ. Autologous bone marrow mesenchymal cell induced chondrogenesis for the treatment of osteoarthritis of knee. Tissue engineering and regenerative medicine. 2016 Apr;13:200-9.
4. Kim SJ, Koo OJ, Park HJ, Moon JH, da Torre BR, Javaregowda PK, Kang JT, Park SJ, Saadeldin IM, Choi JY, Lee BC. Oct4 overexpression facilitates proliferation of porcine fibroblasts and development of cloned embryos. Zygote. 2015 Oct;23(5):704-11.
5. Palaksha KJ, Shin GW, Kim YR, Jung TS. Evaluation of non-specific immune components from the skin mucus of olive flounder (Paralichthys olivaceus). Fish & shellfish immunology. 2008 Apr 1;24(4):479-88.