Our research work with a focus on anticancer studies, specifically on secondary metabolites from endophytes and tetracycline condensed quinoline compounds. Our work primarily involves investigating the potential of these compounds in combating cancer.

A significant aspect of our research involves the development of patient tissue-derived primary cell cultures in conducting cell-based assays for drug screening and toxicological studies. This approach allows us to evaluate the efficacy and potential toxicity of various compounds on cancer cells.

In addition to our experience in anticancer studies, we possess extensive knowledge and hands-on experience in the field of protein and enzyme purification.

Advancing cancer research, along with our proficiency in cell-based assays and protein purification techniques, makes us an asset in the pursuit of new therapeutic strategies. With this deep understanding of the intricate mechanisms underlying cancer development and our expertise in experimental techniques, we contribute significantly to the scientific community's efforts in developing effective treatments against this devastating disease.

1. Kiran Kumar HN, Rohit Kumar HG, Khandagale AS, Advirao GM. In Vivo Antitumor, Pharmacological and Toxicological Study of Pyrimido [4', 5': 4, 5] thieno (2, 3-b) quinoline with 9-hydroxy-4-(3-diethylaminopropylamino) and 8-methoxy-4-(3-diethylaminopropylamino) Substitutions. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents). 2021 Nov 1;21(17):2419-28.
2. Abhilash N, Ajay SK, Ramesh KV, Math RK. Lasiosiphon glaucus a potent ethnobotanical medicinal plant against breast cancer targeting multiple pathways: an invitro study. Advances in Traditional Medicine. 2022 Jan 9:1-8.
3. Kenchappa PG, Karthik Y, Vijendra PD, Hallur RL, Khandagale AS, Pandurangan AK, Jayanna SG, Alshehri MA, Alasmari A, Sayed S, Shantaram M. In vitro evaluation of the neuroprotective potential of Olea dioica against A beta peptide-induced toxicity in human neuroblastoma SH-SY5Y cells. Frontiers in Pharmacology. 2023 May 10;14:1139606.
4. Nivya MT, Patil RK, Rao GM, Khandagale AS, Somashekarappa HM, Ananda D, Manjunath HM, Joshi CG. Cytotoxicity based screening for radioprotective properties of methanolic extract of Tragia involucrata L. on cultured human peripheral lymphocytes exposed to gamma radiation.
5. Rathore SS, Murthy HS, Mamun MA, Nasren S, Rakesh K, Kumar BT, Abhiman PB, Khandagale AS. Nano-selenium supplementation to ameliorate nutrition physiology, immune response, antioxidant system and disease resistance against Aeromonas hydrophila in monosex Nile tilapia (Oreochromis niloticus). Biological trace element research. 2021 Aug;199:3073-88.